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Alam MM, Kishino A, Sung E, Sekine H, Abe T, Murakami S, et al

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In different cell types, activation of necroptosis can be triggered by death receptors of the TNF family, including TNF receptor superfamily member 1A (TNFRSF1A/TNFR1), FAS, and TNF-related apoptosis-inducing ligand (TRAIL) receptors (TNF receptor superfamily member 10a [TNFRSF10A/TRAILR1] and TNF receptor superfamily member 10b [TNFRSF10B/TRAILR2]), that typically induce apoptosis

All three significantly altered factors were cytokines in the IL-17 family (IL-17A, IL-17B, IL-17D) ( Figures 8AC )

And metabolomics analysis showed that arachidonic acid metabolism, tryptophan metabolism, steroid biosynthesis and other metabolic pathways were related to the mechanism of action of ginger-ginseng herb pair