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Most or all of these are common in women who are overweight: Ultra-processed foods Low fiber intake Low protein diets Imbalanced gut flora Lack of short-chain fatty acids Chronic inflammation Poor quality sleep Chronic stress or high cortisol Obesity Insulin resistance/prediabetes Poor vagal nerve function Aging The critical point here is that all but one of those factors are largely or totally within our control

Phase II at minimum, with a credible safety analysis

Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration | BMJ

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