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Insert the needle at the correct angle90 degrees for intramuscular injections and 45 to 90 degrees for subcutaneous injections

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doi: 10.2174/1381612825666190215121712

Notably, Smad3 , which acts primarily downstream of the TGF-activin pathway and is predicted to drive early gene expression changes in HD 23 , was significantly upregulated in the iSPN + mut subpopulation at 8 months (Extended Data Fig