In recent years, extensive research on the interactions between APP and liquids has garnered significant attention
However, human clinical trials were primarily small, observational studies in elderly Russian patients focusing on biomarkers like cortisol, melatonin, and cholesterol
doi:10.1002/ana.410360305 Pocernich CB, Butterfield DA
J Cardiovasc Pharmacol 54:391398 Ghibu S, Delemasure S, Richard C, Guilland JC, Martin L, Gambert S, Rochette L, Vergely C (2012) General oxidative stress during doxorubicin-induced cardiotoxicity in rats: absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acid
Mechanistically, DOX stabilizes the copper importer SLC31A1 (CTR1) by inhibiting its proteasomal degradation and downregulating the copper efflux transporter ATPase Copper Transporting Beta (ATP7B), leading to a net increase in cellular copper [17, 76]